CFTR Modulator Treatment and Sweat Chloride in Cystic Fibrosis Patients

Study Description

This study will collect sweat chloride values from 5000 Cystic Fibrosis (CF) patients using CFTR modulator therapies. Eligible subjects taking a CFTR modulator for at least 3 months will provide sweat samples for analysis. Clinical data will be collected from the Cystic Fibrosis Foundation Patient Registry. Patients who switch to a new modulator will be re-enrolled for a new sweat chloride value.

Study Details

Registry ID:

NCT03350828

Conditions:

Cystic Fibrosis

Phase:

Target Enrollment:

5,000 participants

Start Date:

January 15, 2018

Age Range:

0.333333–999 years

Healthy Volunteers:

No

Study Locations (56 sites)

• Boston Children's Hospital
  Boston, MassachusettsUnited States, United States
• Massachusetts General Hospital
  Boston, MassachusettsUnited States, United States
• Yale University School of Medicine
  New Haven, ConnecticutUnited States, United States
• Dartmouth Hitchcock Medical Center
  Lebanon, New HampshireUnited States, United States
• New York Medical College at Westchester Medical Center
  Valhalla, New YorkUnited States, United States
• Children's Hospital of Philadelphia
  Philadelphia, PennsylvaniaUnited States, United States
• John Hopkins Hospital
  Baltimore, MarylandUnited States, United States
• The Nemours Children's Clinic - Orlando
  Orlando, FloridaUnited States, United States
• Medical University of South Carolina
  Charleston, South CarolinaUnited States, United States
• Hershey Medical Center Pennsylvania State University
  Hershey, PennsylvaniaUnited States, United States
• University of North Carolina at Chapel Hill
  Chapel Hill, North CarolinaUnited States, United States
• University of Florida
  Gainesville, FloridaUnited States, United States
• West Virginia University - Morgantown
  Morgantown, West VirginiaUnited States, United States
• Children's Hospital of Pittsburgh of UPMC
  Pittsburgh, PennsylvaniaUnited States, United States
• The Cystic Fibrosis Center of Western New York
  Buffalo, New YorkUnited States, United States
• Emory University
  Atlanta, GeorgiaUnited States, United States
• Children's Healthcare of Atlanta and Emory University
  Atlanta, GeorgiaUnited States, United States
• Children's Hospital Medical Center of Akron
  Akron, OhioUnited States, United States
• Rainbow Babies and Children's Hospital/University Hospitals Cleveland Medical Center
  Cleveland, OhioUnited States, United States
• Nationwide Children's Hospital
  Columbus, OhioUnited States, United States
• Nemours Children's Clinic - Pensacola
  Pensacola, FloridaUnited States, United States
• University of Kentucky
  Lexington, KentuckyUnited States, United States
• The Children's Hospital Alabama, University of Alabama at Birmingham
  Birmingham, AlabamaUnited States, United States
• Cincinnati Children's Hospital Medical Center
  Cincinnati, OhioUnited States, United States
• Children's Hospital of Michigan
  Detroit, MichiganUnited States, United States
• Toledo Children's Hospital
  Toledo, OhioUnited States, United States
• University of Michigan, Michigan Medicine
  Ann Arbor, MichiganUnited States, United States
• Vanderbilt Children's Hospital
  Nashville, TennesseeUnited States, United States
• Riley Hospital for Children
  Indianapolis, IndianaUnited States, United States
• Helen DeVos Children's Hospital
  Grand Rapids, MichiganUnited States, United States
• University of Tennessee CF Care and Research Center
  Memphis, TennesseeUnited States, United States
• University of Chicago
  Chicago, IllinoisUnited States, United States
• Ann & Robert H. Lurie Children's Hospital of Chicago
  Chicago, IllinoisUnited States, United States
• Children's Hospital of Wisconsin
  Milwaukee, WisconsinUnited States, United States
• St. Louis Children's Hospital
  Saint Louis, MissouriUnited States, United States
• SSM Health Cardinal Glennon Children's Hospital
  Saint Louis, MissouriUnited States, United States
• SSM Health Cardinal Glennon Children's Hospital
  Saint Louis, MissouriUnited States, United States
• St. Louis Children's Hospital
  Saint Louis, MissouriUnited States, United States
• SSM Health Cardinal Glennon Children's Hospital
  St Louis, MissouriUnited States, United States
• St. Louis Children's Hospital
  St Louis, MissouriUnited States, United States
• University of Arkansas for Medical Sciences
  Little Rock, ArkansasUnited States, United States
• University of Wisconsin
  Madison, WisconsinUnited States, United States
• Baylor College of Medicine
  Houston, TexasUnited States, United States
• University of Texas Southwestern / Children's Health
  Dallas, TexasUnited States, United States
• University of Texas Southwestern Medical Center
  Dallas, TexasUnited States, United States
• Children's Mercy Kansas City
  Kansas City, MissouriUnited States, United States
• University of Kansas Medical Center
  Kansas City, KansasUnited States, United States
• The Minnesota Cystic Fibrosis Center
  Minneapolis, MinnesotaUnited States, United States
• Children's Hospital Colorado
  Aurora, ColoradoUnited States, United States
• National Jewish Health
  Denver, ColoradoUnited States, United States
• Primary Children's Cystic Fibrosis Center
  Salt Lake City, UtahUnited States, United States
• University of California San Diego
  La Jolla, CaliforniaUnited States, United States
• Childrens Hospital Los Angeles
  Los Angeles, CaliforniaUnited States, United States
• Oregon Health Sciences University
  Portland, OregonUnited States, United States
• Seattle Children's Hospital
  Seattle, WashingtonUnited States, United States
• University of Washington Medical Center
  Seattle, WashingtonUnited States, United States

Interested in Participating?

Check your eligibility and learn more about this study on TrialScreen.

View full study details and check eligibility →