A Phase 1 study of BGB-B2033 in solid tumors

Study Description

A study to evaluate the safety and effectiveness of an experimental drug called BGB-B2033, alone or in combination with another drug called tislelizumab, in people with advanced or metastatic solid tumors

Study Details

Registry ID:

NCT06427941

Conditions:

Metastatic Hepatocellular Carcinoma, Local Advanced Hepatocellular Carcinoma, Alpha-fetoprotein (AFP)-Producing Gastric Cancer, Extragonadal Yolk Sac Tumors, Glypican-3 (GPC3)-Positive Squamous Non-small Cell Lung Cancer

Phase:

Phase 1,Phase 2

Target Enrollment:

630 participants

Start Date:

July 23, 2024

Age Range:

18–999 years

Healthy Volunteers:

No

Study Locations (54 sites)

• Severance Hospital Yonsei University Health System
  SeodaemunGu, Seoul TeugbyeolsiSouth Korea, South Korea
• Samsung Medical Center
  GangnamGu, Seoul TeugbyeolsiSouth Korea, South Korea
• Cha Bundang Medical Center, Cha University
  BundangGu SeongnamSi, Gyeonggi-doSouth Korea, South Korea
• Cancer Institute Hospital of Jfcr
  Kotoku, TokyoJapan, Japan
• Tokyo Metropolitan Komagome Hospital
  Bunkyoku, TokyoJapan, Japan
• Asan Medical Center
  SongpaGu, Seoul TeugbyeolsiSouth Korea, South Korea
• Hospital Da Bahia
  SalvadorBrazil, Brazil
• Irccs Istituto Nazionale Tumori Fondazione Pascale
  NaplesItaly, Italy
• Iov Istituto Oncologico Veneto Irccs
  PadovaItaly, Italy
• Irccs Humanitas Research Hospital
  RozzanoItaly, Italy
• Fondazione Policlinico Universitario Agostino Gemelli
  RomaItaly, Italy
• Centre Hospitalier Universitaire Nantes Hotel Dieu
  NantesFrance, France
• Institut Gustave Roussy
  VillejuifFrance, France
• Hopital Beaujon
  ClichyFrance, France
• Icesp Instituto Do Cancer Do Estado de Sao Paulo Octavio Frias de Oliveira
  São PauloBrazil, Brazil
• Fundacao Pio Xii Hospital de Amor de Barretos
  BarretosBrazil, Brazil
• Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto
  São José do Rio PretoBrazil, Brazil
• Centro Gaucho Integrado de Oncologia Hospital Mae de Deus
  Porto AlegreBrazil, Brazil
• Hospital Oncologico
  Rio PiedrasPuerto Rico, Puerto Rico
• Memorial Sloan Kettering Cancer Center Mskcc
  New York, New YorkUnited States, United States
• Upmc Hillman Cancer Center(Univ of Pittsburgh)
  Pittsburgh, PennsylvaniaUnited States, United States
• University of Alabama At Birmingham Hospital
  Birmingham, AlabamaUnited States, United States
• Scri Oncology Partners
  Nashville, TennesseeUnited States, United States
• City of Hope Chicago Cancer Center
  Zion, IllinoisUnited States, United States
• The University of Texas Md Anderson Cancer Center
  Houston, TexasUnited States, United States
• Sichuan Cancer Hospital and Institute
  Chengdu, SichuanChina, China
• Chongqing University Cancer Hospital
  Chongqing, Chongqing MunicipalityChina, China
• Guangxi Medical University Cancer Hospital Wuxiang Branch
  Nanning, GuangxiChina, China
• Nanfang Hospital of Southern Medical University
  Guangzhou, GuangdongChina, China
• Zhujiang Hospital of Southern Medical University
  Guangzhou, GuangdongChina, China
• Hunan Cancer Hospital
  Changsha, HunanChina, China
• City of Hope Phoenix Cancer Center
  Goodyear, ArizonaUnited States, United States
• Union Hospital of Tongji Medical College, Huazhong University of Science and Technology
  Wuhan, HubeiChina, China
• Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology
  Wuhan, HubeiChina, China
• The Second Affiliated Hospital of Nanchang Universityhongjiaozhou Branch
  Nanchang, JiangxiChina, China
• The Second Affiliated Hospital of Nanchang University
  Nanchang, JiangxiChina, China
• The Fourth Hospital of Hebei Medical University
  Shijiazhuang, HebeiChina, China
• Anhui Provincial Hospital
  Hefei, AnhuiChina, China
• Mengchao Hepatobiliary Hospital of Fujian Medical University
  Fuzhou, FujianChina, China
• The Affiliated Hospital of Xuzhou Medical University
  Xuzhou, JiangsuChina, China
• City of Hope National Medical Center
  Duarte, CaliforniaUnited States, United States
• Lishui Central Hospital
  Lishui, ZhejiangChina, China
• The First Affiliated Hospital of Wenzhou Medical University
  Wenzhou, ZhejiangChina, China
• The First Affiliated Hospital, Zhejiang University School of Medicine
  Hangzhou, ZhejiangChina, China
• Upmc Hillman Cancer Center
  Puyallup, WashingtonUnited States, United States
• Seoul National University Hospital
  Seoul, Seoul TeugbyeolsiSouth Korea, South Korea
• Seoul National University Bundang Hospital
  Seongnam-si, Gyeonggi-doSouth Korea, South Korea
• Chungbuk National University Hospital
  Cheongju-si, ChungcheongbukdoSouth Korea, South Korea
• Cha Bundang Medical Center, Cha University
  BundangGu SeongnamSi, Gyeonggi-doKorea, Republic of, Korea, Republic of
• Samsung Medical Center
  GangnamGu, Seoul TeugbyeolsiKorea, Republic of, Korea, Republic of
• Severance Hospital Yonsei University Health System
  SeodaemunGu, Seoul TeugbyeolsiKorea, Republic of, Korea, Republic of
• Harbin Medical University Cancer Hospital
  Harbin, HeilongjiangChina, China
• Kindai University Hospital
  Sakai, OsakaJapan, Japan
• Auckland City Hospital
  AucklandNew Zealand, New Zealand

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