Phase I Trial of ZW25 in Patients With Locally Advanced (Unresectable) and/or Metastatic HER2-expressing Cancers

Unknown Phase 1 NCT02892123

Study Description

This is a first-in-human, 3-part study to investigate the safety, tolerability, and effectiveness of ZW25 (zanidatamab) by itself and combined with selected chemotherapy agents in patients with locally advanced (unresectable) and/or metastatic human epidermal growth factor receptor 2 (HER2)-expressing cancers. This study will also the evaluate the way the body absorbs, distributes, and eliminates ZW25 (pharmacokinetics or PK).

Study Details

Registry ID:: NCT02892123
Conditions:: HER2-expressing Cancers
Phase:: Phase 1
Target Enrollment:: 279 participants
Start Date:: September 30, 2016
Age Range:: 18–999 years
Healthy Volunteers:: No

Study Locations (18 sites)

Jewish General Hospital
Montréal, QuebecCanada, Canada
University of Ottawa
Ottawa, OntarioCanada, Canada
Princess Margaret Cancer Centre
Toronto, OntarioCanada, Canada
University of Alabama
Birmingham, AlabamaUnited States, United States
Sarah Cannon - Tennessee Oncology
Nashville, TennesseeUnited States, United States
Rush University Medical Center
Chicago, IllinoisUnited States, United States
MD Anderson Cancer Center
Houston, TexasUnited States, United States
South Texas Accelerated Research Therapeutics (START)
San Antonio, TexasUnited States, United States
University of Colorado Cancer Center
Aurora, ColoradoUnited States, United States
Hoag Family Cancer Institute
Newport Beach, CaliforniaUnited States, United States
USC/Norris Cancer Center
Los Angeles, CaliforniaUnited States, United States
Northwest Medical Specialties
Tacoma, WashingtonUnited States, United States
Seoul National University Hospital
SeoulKorea, Republic of, Korea, Republic of
Severance Hospital
SeoulKorea, Republic of, Korea, Republic of
Asan Medical Center
SeoulKorea, Republic of, Korea, Republic of
Samsung Medical Center
SeoulKorea, Republic of, Korea, Republic of
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-DoKorea, Republic of, Korea, Republic of
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-doKorea, Republic of, Korea, Republic of

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