JNJ-75348780 for Relapsed Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia

Study Description

This study aims to determine the recommended Phase 2 dose(s) and optimal dosing schedule(s) of JNJ-75348780 for relapsed B-cell Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia. JNJ-75348780 is a human bispecific antibody that targets CD3 on T-cells and CD22 on malignant B-lymphocytes to induce cytotoxicity and cytokine production. The study involves a screening phase, treatment phase, and post-treatment phase with efficacy assessments such as radiographic imaging and safety monitoring throughout the up-to-2-year-10-month study duration.

Study Details

Registry ID:

NCT04540796

Conditions:

Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell

Phase:

Phase 1

Target Enrollment:

147 participants

Start Date:

November 20, 2020

Age Range:

18–999 years

Healthy Volunteers:

No

Study Locations (70 sites)

• Hosp Univ Fund Jimenez Diaz
  MadridSpain, Spain
• Hosp. Univ. Fund. Jimenez Diaz
  MadridSpain, Spain
• Hosp. Clinico Univ. de Salamanca
  Salamanca, SalamancaSpain, Spain
• Hosp. Clinico Univ. de Salamanca
  SalamancaSpain, Spain
• Hosp Clinico Univ de Salamanca
  SalamancaSpain, Spain
• Hospital de Vall D'Hebron
  Barcelona, BarcelonaSpain, Spain
• Hosp. Univ. Germans Trias I Pujol
  Barcelona, BarcelonaSpain, Spain
• Hosp. Univ. Germans Trias I Pujol
  BarcelonaSpain, Spain
• Hospital de Vall D'Hebron
  BarcelonaSpain, Spain
• Clinica Univ. de Navarra
  PamplonaSpain, Spain
• Centre hospitalier Lyon-Sud
  Pierre BeniteFrance, France
• Centre hospitalier Lyon-Sud
  Pierre BeniteFrance, France
• CHU Nantes
  NANTES Cedex 1France, France
• CHU Nantes
  NANTES Cedex 1France, France
• Tel Aviv Sourasky MC
  Tel AvivIsrael, Israel
• Sheba Medical Center
  Ramat GanIsrael, Israel
• Hadassah Medical Center
  JerusalemIsrael, Israel
• Carmel Medical Center
  HaifaIsrael, Israel
• Rambam Medical Center
  HaifaIsrael, Israel
• Plymouth Hospital NHS Trust
  PlymouthUnited Kingdom, United Kingdom
• CHRU de Lille Hopital Claude Huriez
  LilleFrance, France
• CHRU de Lille - Hôpital Claude Huriez
  LilleFrance, France
• King s College Hospital
  LondonUnited Kingdom, United Kingdom
• King's College Hospital
  LondonUnited Kingdom, United Kingdom
• Kings College Hospital
  LondonUnited Kingdom, United Kingdom
• Leicester Royal Infirmary
  Leicester, LeicestershireUnited Kingdom, United Kingdom
• Leicester Royal Infirmary
  LeicesterUnited Kingdom, United Kingdom
• The Christie Nhs Foundation Trust
  Manchester, Greater ManchesterUnited Kingdom, United Kingdom
• The Christie Nhs Foundation Trust
  ManchesterUnited Kingdom, United Kingdom
• Icahn School of Medicine at Mount Sinai
  New York, New YorkUnited States, United States
• University of Alabama at Birmingham
  Birmingham, AlabamaUnited States, United States
• The University of Texas MD Anderson Cancer Center
  Houston, TexasUnited States, United States
• University of Oklahoma Stephenson Cancer Center
  Oklahoma City, OklahomaUnited States, United States
• Sun Yat-Sen University Cancer Center
  GuangzhouChina, China
• Sun Yat-Sen University Cancer Center
  Guangzhou, GuangdongChina, China
• Union Hospital Tongji Medical College of Huazhong University of Science and Technology
  WuhanChina, China
• Union Hospital Tongji Medical College of Huazhong University of Science and Technology
  Wuhan, HubeiChina, China
• Linear Clinical Research Ltd
  Nedlands, Western AustraliaAustralia, Australia
• Linear Clinical Research Ltd
  NedlandsAustralia, Australia
• National Cheng Kung University Hospital
  Tainan CityTaiwan, Taiwan
• National Cheng Kung University Hospital
  TainanTaiwan, Taiwan
• Chang-Gung Memorial Hospital, Kaohsiung
  Kaohsiung CityTaiwan, Taiwan
• Chang-Gung Memorial Hospital, Kaohsiung
  KaohsiungTaiwan, Taiwan
• China Medical University Hospital
  TaichungTaiwan, Taiwan
• Taichung Veterans General Hospital
  TaichungTaiwan, Taiwan
• Beijing Cancer Hospital
  BeijingChina, China
• Beijing Tongren Hospital, CMU
  BeijingChina, China
• Tianjin Medical University Cancer Institute and Hospital
  TianjinChina, China
• Zhejiang Cancer Hospital
  Hangzhou, ZhejiangChina, China
• Zhejiang Cancer Hospital
  Hang ZhouChina, China
• National Taiwan University Hospital
  TaipeiTaiwan, Taiwan
• Severance Hospital Yonsei University Health System
  SeoulKorea, Republic of, Korea, Republic of
• The Catholic University of Korea Seoul St Marys Hospital
  SeoulSouth Korea, South Korea
• Samsung Medical Center
  SeoulSouth Korea, South Korea
• Asan Medical Center
  SeoulSouth Korea, South Korea
• Severance Hospital Yonsei University Health System
  SeoulSouth Korea, South Korea
• Seoul National University Hospital
  SeoulSouth Korea, South Korea
• The Catholic University of Korea, Seoul St. Mary's Hospital
  SeoulKorea, Republic of, Korea, Republic of
• The Catholic University of Korea Seoul St Marys Hospital
  SeoulKorea, Republic of, Korea, Republic of
• Samsung Medical Center
  SeoulKorea, Republic of, Korea, Republic of
• Asan Medical Center
  SeoulKorea, Republic of, Korea, Republic of
• Severance Hospital, Yonsei University Health System
  SeoulKorea, Republic of, Korea, Republic of
• The Catholic University of Korea Seoul St. Mary's Hospital
  SeoulKorea, Republic of, Korea, Republic of
• Seoul National University Hospital
  SeoulKorea, Republic of, Korea, Republic of
• Osaka University Hospital
  SuitaJapan, Japan
• The Cancer Institute Hospital of JFCR
  TokyoJapan, Japan
• National Cancer Center Hospital
  Chūō, TokyoJapan, Japan
• Tohoku University Hospital
  SendaiJapan, Japan
• Austin Hospital
  HeidelbergAustralia, Australia
• Austin Hospital
  Heidelberg, VictoriaAustralia, Australia

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