A Phase 2 study of ACT001 in DIPG and H3K27-altered HGG

Study Description

A Study to Evaluate the Safety and Effectiveness of ACT001 in Children and Adults with Diffuse Intrinsic Pontine Glioma and H3K27-altered High Grade Glioma

Study Details

Registry ID:

NCT06838676

Conditions:

Diffuse Intrinsic Pontine Gliomas (DIPG), Progressive DIPG, Refractory DIPG, Recurrent DIPG, H3K27-altered High Grade Glioma

Phase:

Phase 2

Target Enrollment:

60 participants

Start Date:

July 10, 2025

Age Range:

1–39 years

Healthy Volunteers:

No

Study Locations (22 sites)

• Hopp Children's Cancer Center at NCT Heidelberg (KiTZ)
  Heidelberg, Baden-WürttembergGermany, Germany
• Nicklaus Children's Hospital
  Miami, FloridaUnited States, United States
• Children's Hospital of Philidelphia
  Philidelphia, PennsylvaniaUnited States, United States
• Children's National Medical Center
  Washington, District of ColumbiaUnited States, United States
• Children's National Medical Center
  Washington D.C., District of ColumbiaUnited States, United States
• Montreal Children's Hospital
  Montréal, QuebecCanada, Canada
• Duke University Medical Center
  Durham, North CarolinaUnited States, United States
• The Hospital for Sick Children (SickKids)
  Toronto, OntarioCanada, Canada
• Emory University/Children's Healthcare of Atlanta
  Atlanta, GeorgiaUnited States, United States
• Nationwide Children's Hospital
  Columbus, OhioUnited States, United States
• Cincinnati Children's Hospital
  Cincinnati, OhioUnited States, United States
• C.S. Mott Children's Hospital
  Ann Arbor, MichiganUnited States, United States
• St. Louis Children's Hospital
  St. Louis, MissouriUnited States, United States
• St. Louis Children's Hospital
  St Louis, MissouriUnited States, United States
• Texas Children's Hospital
  Houston, TexasUnited States, United States
• Children's Hospital Colorado
  Aurora, ColoradoUnited States, United States
• Perth Children's Hospital
  Perth, Western AustraliaAustralia, Australia
• Seattle Children's Hospital
  Seattle, WashingtonUnited States, United States
• Royal Children's Hospital
  Melbourne, VictoriaAustralia, Australia
• Sydney Children's Hospital
  Randwick, New South WalesAustralia, Australia
• Queensland Children's Hospital
  South Brisbane, QueenslandAustralia, Australia
• Starship Children's Hospital
  Auckland, GraftonNew Zealand, New Zealand

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