Multi-center, Randomized，Placebo and Positive Controlled Clinical Study of TPN171H Tablets on Acute Haemodynamics in Patients with Pulmonary Arterial Hypertension
Unknown Phase 2 NCT04483115
Study Description
This study is a phase IIa proof-of-concept study to evaluate the effect of single-dose TPN171H tablets on acute haemodynamic parameters in patients with pulmonary arterial hypertension.The trial is expected to include 60 patients, divided into 6 groups, according to 1:1:1:1:1:1 into the placebo group and the test drugs 2.5mg, 5mg, 10mg group, tadalafil tablets 20mg, 40mg group, each group 10 cases.
Study Details
- Registry ID:
- NCT04483115
- Conditions:
- Pulmonary Arterial Hypertension
- Phase:
- Phase 2
- Target Enrollment:
- 60 participants
- Start Date:
- Healthy Volunteers:
- No
Study Locations (9 sites)
-
Gansu Provincial Hospital
Lanzhou, Gansu, China -
The First Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing, China -
The Second Xiangya Hospital of Central South University
Changsha, Hunan, China -
Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science & Technology
Wuhan, Hubei, China -
First Affiliated Hospital Of Gannan Medical University
Ganzhou, Jiangxi, China -
Peking Union Medical College Hospital
Beijing, Beijing, China -
Peking University First Hospital
Beijing, Beijing, China -
Fuwai Hospital CAMS&PUMC
Beijing, Beijing, China -
Shanghai Pulmonary Hospital
Shanghai, Shanghai, China
Interested in Participating?
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