A Phase 3 study of belzutifan plus fulvestrant in ER+/HER2- metastatic breast cancer

Active, Not Recruiting Phase 2 NCT06428396

Study Description

A study evaluating the efficacy and safety of belzutifan (MK-6482) plus fulvestrant compared to everolimus plus endocrine therapy in adults with estrogen receptor-positive, HER2-negative metastatic breast cancer

Study Details

Registry ID:: NCT06428396
Conditions:: Metastatic Breast Cancer
Phase:: Phase 2
Target Enrollment:: 120 participants
Start Date:: November 27, 2024
Age Range:: 18–999 years
Healthy Volunteers:: No

Study Locations (57 sites)

Faculty of Medicine - Khon Kaen University ( Site 3502)
Muang, Changwat Khon KaenThailand, Thailand
Faculty of Medicine Siriraj Hospital ( Site 3500)
Bangkoknoi, BangkokThailand, Thailand
Faculty of Medicine - Khon Kaen University ( Site 3502)
Muang, Khon KaenThailand, Thailand
The Royal Cornwall Hospital ( Site 1904)
Truro, EnglandUnited Kingdom, United Kingdom
St Bartholomews Hospital ( Site 1900)
London, London, City OfUnited Kingdom, United Kingdom
Ipswich Hospital ( Site 1911)
Ipswich, SuffolkUnited Kingdom, United Kingdom
The Christie Hospital NHS Foundation Trust ( Site 1902)
WithingtonUnited Kingdom, United Kingdom
Centro de Investigaciones Metabólicas (CINME)-Oncology ( Site 0504)
Caba, Buenos AiresArgentina, Argentina
Hospital Británico de Buenos Aires-Oncology ( Site 0500)
Ciudad autónoma de Buenos Aires, Buenos AiresArgentina, Argentina
Instituto Alexander Fleming-Alexander Fleming ( Site 0505)
Ciudad Autónoma de Buenos Aires, CabaArgentina, Argentina
Instituto Alexander Fleming-Alexander Fleming ( Site 0505)
Buenos Aires, Buenos Aires F.D.Argentina, Argentina
Instituto de Investigaciones Clínicas Mar del Plata ( Site 0502)
Mar del Plata, Buenos AiresArgentina, Argentina
Instituto de Oncología de Rosario ( Site 0501)
Rosario, Santa FeArgentina, Argentina
Instituto de Oncología de Rosario ( Site 0501)
Rosario, Santa Fe ProvinceArgentina, Argentina
Sanatorio Allende - Cerro-Oncology ( Site 0506)
Córdoba, CordobaArgentina, Argentina
Hospital Italiano de Córdoba ( Site 0508)
CórdobaArgentina, Argentina
Sanatorio Allende - Cerro-Oncology ( Site 0506)
Córdoba, Córdoba ProvinceArgentina, Argentina
Oncologos Del Occidente ( Site 1200)
Pereira, Risaralda DepartmentColombia, Colombia
Oncologos Del Occidente ( Site 1200)
Pereira, RisaraldaColombia, Colombia
IMAT S.A.S ( Site 1205)
Montería, Departamento de CórdobaColombia, Colombia
IMAT S.A.S ( Site 1205)
Monteria, CordobaColombia, Colombia
Fundacion Valle del Lili ( Site 1204)
Santiago de Cali, Valle del Cauca DepartmentColombia, Colombia
Fundacion Valle del Lili ( Site 1204)
Cali, Valle del Cauca DepartmentColombia, Colombia
Fundacion Valle del Lili ( Site 1204)
Cali, Valle Del CaucaColombia, Colombia
Bradfordhill ( Site 4100)
Santiago, Region M. de SantiagoChile, Chile
Pontificia Universidad Catolica de Chile ( Site 4108)
Santiago, Region M. De SantiagoChile, Chile
FALP ( Site 4102)
Santiago, Region M. De SantiagoChile, Chile
Bradfordhill ( Site 4100)
Santiago., Region M. De SantiagoChile, Chile
Centro de Investigación del Maule ( Site 4106)
Talca, Maule RegionChile, Chile
Centro de Investigación del Maule ( Site 4106)
Talca, MauleChile, Chile
MD Anderson Cancer Center at Cooper ( Site 0024)
Camden, New JerseyUnited States, United States
Jewish General Hospital ( Site 0400)
Montreal, QuebecCanada, Canada
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital ( Site 0011)
Marietta, GeorgiaUnited States, United States
Southeastern Regional Medical Center ( Site 0010)
Newnan, GeorgiaUnited States, United States
Medical College of Wisconsin - Froedtert Hospital ( Site 0014)
Milwaukee, WisconsinUnited States, United States
CHRISTUS Highland ( Site 0005)
Shreveport, LouisianaUnited States, United States
SSM Health Dean Medical Group - South Madison Campus Health Research/Circuit Clinical ( Site 0034)
Madison, WisconsinUnited States, United States
MD Anderson ( Site 0015)
Houston, TexasUnited States, United States
Songklanagarind Hospital ( Site 3501)
Hat Yai, SongkhlaThailand, Thailand
Songklanagarind Hospital ( Site 3501)
Hat Yai, Changwat SongkhlaThailand, Thailand
Faculty of Medicine Siriraj Hospital ( Site 3500)
Bangkoknoi, Krung Thep Maha NakhonThailand, Thailand
Mays Cancer Center ( Site 0022)
San Antonio, TexasUnited States, United States
Western Regional Medical Center ( Site 0006)
Goodyear, ArizonaUnited States, United States
City of Hope - Phoenix ( Site 0006)
Goodyear, ArizonaUnited States, United States
Moores Cancer Center at UC San Diego Health ( Site 0025)
La Jolla, CaliforniaUnited States, United States
National Cheng Kung University Hospital ( Site 3300)
Tainan CityTaiwan, Taiwan
National Cheng Kung University Hospital ( Site 3300)
TainanTaiwan, Taiwan
USC Norris Oncology Hematology Newport Beach ( Site 0029)
Newport Beach, CaliforniaUnited States, United States
USC/Norris Comprehensive Cancer Center ( Site 0013)
Los Angeles, CaliforniaUnited States, United States
Cedars Sinai Medical Center ( Site 0012)
Beverly Hills, CaliforniaUnited States, United States
National Taiwan University Hospital ( Site 3301)
TaipeiTaiwan, Taiwan
National Taiwan University Cancer Center ( Site 3302)
TaipeiTaiwan, Taiwan
Renown Regional Medical Center ( Site 0018)
Reno, NevadaUnited States, United States
Samsung Medical Center ( Site 3101)
SeoulSouth Korea, South Korea
Seoul National University Hospital ( Site 3100)
SeoulSouth Korea, South Korea
Seoul National University Hospital ( Site 3100)
SeoulKorea, Republic of, Korea, Republic of
Samsung Medical Center ( Site 3101)
SeoulKorea, Republic of, Korea, Republic of

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