Phase 2 Study Investigating Efficacy and Safety of Anti-PD-1 Monoclonal Antibody Tislelizumab (BGB-A317) Combined With or Without Anti-TIGIT Monoclonal Antibody BGB-A1217 in Patients With Previously Treated Recurrent or Metastatic Cervical Cancer

Study Description

This study tested how well and how safely the drug tislelizumab, given either alone or with another drug called ociperlimab (BGB-A1217), worked in people with cervical cancer that had come back or spread after previous treatments. The study included two groups and took place at multiple medical centers.

Study Details

Registry ID:

NCT04693234

Conditions:

Cervical Cancer

Phase:

Phase 2

Target Enrollment:

178 participants

Start Date:

February 15, 2021

Age Range:

18–999 years

Gender:

Female

Healthy Volunteers:

No

Study Locations (77 sites)

• Public Non-Profit Institution "Precarpathian Oncology Center Of Ivano-Frankivsk Regional Council"
  Ivano-Frankivsk Oblast, Ivano-FrankivskUkraine, Ukraine
• Medical and diagnostic center of private enterprise private production company "acinus"
  Kirovograd, Kirovohradska OblastUkraine, Ukraine
• Acibadem city clinic tokuda umhat ead, department of medical oncology
  Sofia, Sofia CityBulgaria, Bulgaria
• Medical center nadezhda clinical eood
  Sofia, Sofia CityBulgaria, Bulgaria
• Medical center nadezhda clinical eood
  SofiaBulgaria, Bulgaria
• Acibadem city clinic tokuda umhat ead, department of medical oncology
  SofiaBulgaria, Bulgaria
• "Mhat uni hospital" ood
  PanagyurishteBulgaria, Bulgaria
• Complex Oncology Center Rousse Eood
  RuseBulgaria, Bulgaria
• Przychodnia lekarska komed
  KoninPoland, Poland
• Volyn Regional Medical Center Of Oncology
  Luts'kUkraine, Ukraine
• Szpitale Pomorskie Spółka z ograniczoną odpowiedzialnością
  GdyniaPoland, Poland
• Medical center of llc oncolife
  KropyvnytskyiUkraine, Ukraine
• Medical and diagnostic center of private enterprise private production company "acinus"
  Kropyvnytskyi, Kirovohradska OblastUkraine, Ukraine
• National Cancer Institute
  KievUkraine, Ukraine
• State healthcare institution oncologic dispensary no. 2 - health department of krasnodar region
  Krasnodar, Krasnodar KraiRussian Federation, Russian Federation
• State healthcare institution oncologic dispensary no. 2 - health department of krasnodar region
  Krasnodar Krai, Krasnodar KraiRussian Federation, Russian Federation
• Sbhi of stavropol region "pyatigorsk interdistrict oncologic dispensary"
  Pyatigorsk, Stavropol RegionRussian Federation, Russian Federation
• Communal Non-Profit Enterprise Of Sumy Regional Council Sumy Regional Clinical Oncological Dispensar
  Sumy, Sumska OblastUkraine, Ukraine
• Oncological Scientific Center LLC
  PesochnyRussian Federation, Russian Federation
• Fsbi of higher education"ogarev mordovia state university"
  Saransk, Mordovia RepublicRussian Federation, Russian Federation
• Arkhangelsk regional clinical oncological dispensary
  Arkhangel'skRussian Federation, Russian Federation
• Arkhangelsk regional clinical oncological dispensary
  Arkhangel'skRussian Federation, Russian Federation
• State budgetary healthcare institution-chelyabinsk regional clinical center of oncology and nuclear
  ChelyabinskRussian Federation, Russian Federation
• Affiliated Cancer Hospital of Xinjiang Medical University
  Urumqi, XinjiangChina, China
• Songklanagarind Hospital, Prince of Songkla University
  Hat YaiThailand, Thailand
• Siriraj Hospital
  Bangkok Noi district, BangkokThailand, Thailand
• Siriraj Hospital
  Bangkok Noi, BangkokThailand, Thailand
• Phramongkutklao Hospital
  RatchathewiThailand, Thailand
• Srinagarind Hospital (Khon Kaen University)
  Khon KaenThailand, Thailand
• Gansu Provincial Hospital
  Lanzhou, GansuChina, China
• Southwest Hospital
  Chongqing, ChongqingChina, China
• Chongqing Cancer Hospital
  Chongqing, ChongqingChina, China
• The Tumor Hospital Affiliated to Guangxi Medical University
  Nanning, GuangxiChina, China
• Hainan Cancer Hospital
  Haikou, HainanChina, China
• General Hospital of Ningxia Medical University
  Yinchuan, NingxiaChina, China
• The First Affiliated Hospital of Xi'an Jiaotong University
  Xi'an, ShanxiChina, China
• Sun yat-sen memorial hospital, sun yat-sen university (south)
  Guanzhou, GuangdongChina, China
• Hunan Cancer Hospital - GCP Office
  Changsha, HunanChina, China
• Union Hospital of Tongji Medical College, Huazhong University of Science and Technology
  Wuhan, HubeiChina, China
• Hubei Cancer Hospital - Oncology
  Wuhan, HubeiChina, China
• Second Hospital Of Shanxi Medical University
  Taiyuan, ShanxiChina, China
• Henan Cancer Hospital - Oncology
  Zhengzhou, HenanChina, China
• The First Affiliated Hospital of Nanchang University Branch Donghu
  Nanchang, JiangxiChina, China
• The First Affiliated Hospital of Xiamen University - Oncology
  XiamenChina, China
• Anhui Provincial Cancer Hospital
  Hefei, AnhuiChina, China
• Xuzhou Cancer Hospital
  Xuzhou, JiangsuChina, China
• National Cheng Kung University Hospital
  TainanTaiwan, Taiwan
• Linkou Chang Gung Memorial Hospital
  TainanTaiwan, Taiwan
• Chi Mei Hospital, Liouying
  TainanTaiwan, Taiwan
• Qilu Hospital of Shandong University
  Jinan, ShandongChina, China
• Beijing Cancer Hosptial
  BeijingChina, China
• Cancer Hospital Chinese Academy of Medical Sciences
  BeijingChina, China
• Tianjin Medical University Cancer institute & Hospital
  Tianjin, TianjinChina, China
• Linyi Cancer Hospital
  ShandongChina, China
• The First Affiliated Hospital, Zhejiang University School of Medicine
  Hangzhou, ZhejiangChina, China
• Zhejiang Cancer Hospital
  Hangzhou, ZhejiangChina, China
• Taipei Veterans General Hospital
  TaipeiTaiwan, Taiwan
• National Taiwan University Hospital
  TaipeiTaiwan, Taiwan
• Mackay Memorial Hospital
  TaipeiTaiwan, Taiwan
• Obstetrics and Gynecology Hospital of Fudan University
  Shanghai, ShanghaiChina, China
• Liaoning Cancer Hospital & Institute - Medical Oncology - Oncology
  Shenyang, LiaoningChina, China
• Seoul National University Bundang Hospital
  Gyeonggi-doKorea, Republic of, Korea, Republic of
• Ajou University Hospital
  Gyeonggi-doKorea, Republic of, Korea, Republic of
• National Cancer Center
  Gyeonggi-doKorea, Republic of, Korea, Republic of
• Severance Hospital, Yonsei University Health System
  SeoulKorea, Republic of, Korea, Republic of
• Seoul National University Hospital
  SeoulKorea, Republic of, Korea, Republic of
• Samsung Medical Center
  SeoulKorea, Republic of, Korea, Republic of
• Korea University Guro Hospital
  SeoulKorea, Republic of, Korea, Republic of
• Korea Institute of Radiological & Medical Sciences
  SeoulKorea, Republic of, Korea, Republic of
• Gangnam Severance Hospital
  SeoulKorea, Republic of, Korea, Republic of
• Asan Medical Center
  SeoulKorea, Republic of, Korea, Republic of
• Seoul National University Bundang Hospital
  Gyeonggi-doKorea, Republic of, Korea, Republic of
• National Cancer Center
  Gyeonggi-doKorea, Republic of, Korea, Republic of
• Ajou University Hospital
  Gyeonggi-doKorea, Republic of, Korea, Republic of
• Kyemyung University Dongsan Hospital
  DaeguKorea, Republic of, Korea, Republic of
• Keimyung University Dongsan Medical Center
  DaeguKorea, Republic of, Korea, Republic of
• Jilin Guowen Hospital
  Jilin, JilinChina, China

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