Understanding Body's Stress Hormone Levels After Baxdrostat Treatment in High Blood Pressure

Completed Phase 2 NCT06336356

Study Description

This study focuses on measuring how well the body's stress hormone, known as cortisol, can be released when it's needed in people who have high blood pressure that hasn't improved with usual treatments. Cortisol is important for many body functions, and is released when we're stressed or need extra energy. We're looking at how cortisol is released in response to a special medical test, called the ACTH stimulation test, both before any treatment is given, and again after 8 weeks of taking a new medication called baxdrostat, or a 'dummy' pill called placebo. We're trying to see if baxdrostat affects the body's ability to make cortisol compared to the placebo. Participants will have an equal chance of receiving either the actual medicine or placebo. During this study, which will last about 16 weeks, doctors will track the health and safety of the participants regularly. No results or conclusions from this study will be shared here.

Study Details

Registry ID:
NCT06336356
Conditions:
Uncontrolled Hypertension
Phase:
Phase 2
Target Enrollment:
48 participants
Start Date:
Healthy Volunteers:
No

Study Locations (11 sites)

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