A Phase 3 study of etavopivat in sickle cell disease

Recruiting Phase 3 NCT06612268

Study Description

Evaluating the effectiveness of etavopivat in reducing sickle cell pain crises and improving overall health in people with sickle cell disease

Study Details

Registry ID:: NCT06612268
Conditions:: Sickle Cell Disease
Phase:: Phase 3
Target Enrollment:: 408 participants
Start Date:: February 17, 2025
Healthy Volunteers:: No

Study Locations (229 sites)

Lagos University Teaching Hospital, Lagos
LagosNigeria, Nigeria
Kintampo Health Research Centre (KHRC), Kintampo, Ghana
KintampoGhana, Ghana
Kintampo Health Research Centre (KHRC)
Kintampo, Bono EastGhana, Ghana
University College Hospital Paediatric Haematology and Oncology Unit, Ibadan
Ibadan, Oyo StateNigeria, Nigeria
University of Nigeria Teaching Hospital (UNTH)
Ituku-Ozalla, Enugu StateNigeria, Nigeria
University of Nigeria Teaching Hospital, Enugu
EnuguNigeria, Nigeria
Navrongo Health Research Centre, Ghana
NavrongoGhana, Ghana
Navrongo Health Research Centre
Navrongo, Upper East RegionGhana, Ghana
Centre for Sickle Cell Disease Research and Training University of Abuja (CESRTA), Abuja
AbujaNigeria, Nigeria
Centre of Excellence for Sickle Cell Disease Research and Training, University of Abuja (CESRTA)
Abuja, Federal Capital Territory (fct)Nigeria, Nigeria
Makerere University College of Health Sciences
KampalaUganda, Uganda
Joint Clinical Research Centre (JCRC)
KampalaUganda, Uganda
Makerere University College of Health Sciences (MakCHS)
Kampala, Central RegionUganda, Uganda
Joint Clinical Research Centre (JCRC)
Kampala, Central Region (Wakiso District)Uganda, Uganda
Jinja Regional Referral Hospital Children's Ward
JinjaUganda, Uganda
Jinja Regional Referral Hospital
Jinja, Eastern RegionUganda, Uganda
KEMRI Siaya Clinical Research Annex Siaya County Referral Hospital, Siaya
SiayaKenya, Kenya
KEMRI CRDR Siaya Clinical Research Annex, Country Referral Hospital
Siaya, Siaya CountyKenya, Kenya
Ahero Clinical Trials Unit, Kisumu, Kenya
KisumuKenya, Kenya
Ahero Clinical Trials Unit
KisumuKenya, Kenya
International Cancer Institute (ICI)
Eldoret, Uasin Gishu CountyKenya, Kenya
International Cancer Institute (ICI)
Uasin Gishu CountyKenya, Kenya
MultiHemo - Grupo Oncoclínicas
Recife, PernambucoBrazil, Brazil
Gertrude's Children's Hospital, Nairobi
NairobiKenya, Kenya
Gertrude's Children's Hospital
Nairobi, Nairobi CountyKenya, Kenya
Hospital Universitario Virgen del Rocío
SevillaSpain, Spain
Hospital Universitario Virgen del Rocío
SevilleSpain, Spain
Azienda Ospedaliera Ospedali Riuniti Villa Sofia - Cervello
PalermoItaly, Italy
ARNAS (Azienda Ospedaliera di Rilievo Nazionale di Alta Specializzazione) Ospedale Garibaldi
CataniaItaly, Italy
ARNAS Garibaldi Catania - Presidio Ospedaliero Garibaldi-Centro
CataniaItaly, Italy
ARNAS Ospedale Garibaldi
CataniaItaly, Italy
Hospital Gregorio Marañón
MadridSpain, Spain
Hospital Universitario La Paz
MadridSpain, Spain
Hospital Vall d'Hebron
BarcelonaSpain, Spain
A.O.U. Università Studi della Campania "Luigi Vanvitelli"
NaplesItaly, Italy
"Laiko" General Hospital of Athens
AthensGreece, Greece
Childrens' Hospital of Athens "Agia Sofia"
AthensGreece, Greece
Hippokration Hospital
AthensGreece, Greece
University General Hospital Of Ioannina
IoanninaGreece, Greece
Centre Hospitalier Universitaire de Bordeaux-Hopital Pellegrin
BordeauxFrance, France
Centre Hospitalier Universitaire Grenoble Alpes-Site Nord Michallon-1
Grenoble cedex 9France, France
Centre Hospitalier Universitaire Grenoble Alpes-Site Nord Michallon-1
GrenobleFrance, France
Centre Hospitalier Universitaire Grenoble Alpes-Site Nord Michallon
GrenobleFrance, France
Azienda Ospedaliera Universitaria San Luigi Gonzaga
Orbassano, TorinoItaly, Italy
Azienda Ospedaliera Universitaria San Luigi Gonzaga - S.C.D.O. Microcitemie e malattie rare ematologiche
Orbassano, TorinoItaly, Italy
Azienda Ospedale Universita Padova
PadovaItaly, Italy
A.O. Universitaria di Modena
ModenaItaly, Italy
Azienda Ospedaliero Universitaria Di Modena - UOC Pediatria ad indirizzo Oncoematologico
ModenaItaly, Italy
Hospices Civils de Lyon-Hopital Edouard Herriot
Lyon Cedex 03France, France
Hospices Civils de Lyon-Hopital Edouard Herriot
LyonFrance, France
Fondazione IRCCS San Gerardo dei Tintori
MonzaItaly, Italy
"AHEPA" University General Hospital of Thessaloniki
ThessalonikiGreece, Greece
ASST Civili di Brescia, Piazzale Spedali Civili 1, 25123 Brescia
BresciaItaly, Italy
ASST Civili di Brescia
BresciaItaly, Italy
Policlinico GB Rossi
VeronaItaly, Italy
Azienda Ospedaliera Universitaria Integrata Verona Policlinico GB Rossi - Borgo Roma
VeronaItaly, Italy
Azienda Ospedaliera Universitaria Integrata Verona Policlinico GB Rossi - Borgo Roma - Centro Ricerche Cliniche Di Verona S.r.l.
Verona, VenetoItaly, Italy
Azienda Ospedale Universita Padova
PaduaItaly, Italy
Ap-Hp-Hopital Henri Mondor
CréteilFrance, France
Hemorio-Fundarj
Rio de JaneiroBrazil, Brazil
Ap-Hp-Hopital Necker-1
ParisFrance, France
Ap-Hp-Hopital Robert Debre
ParisFrance, France
AP-HP-HOPITAL NECKER_Service d'hématologie
ParisFrance, France
Ap-Hp-Hopital Avicenne
BobignyFrance, France
American University of Beirut Medical Centre
HamraLebanon, Lebanon
Centre Hospitalier Universitaire de Rouen-Hopital Charles Nicolle
Rouen cedexFrance, France
Centre Hospitalier Universitaire de Rouen-Hopital Charles Nicolle
RouenFrance, France
Hospital Nini
TripoliLebanon, Lebanon
Mersin University Medical Faculty Pediatric Hematology
MersinTurkey, Turkey
VM Medical Park Mersin Hospital
MersinTurkey, Turkey
Mersin University Medical Faculty Pediatric Hematology
MersinTurkey (Türkiye), Turkey (Türkiye)
VM Medical Park Mersin Hospital
MersinTurkey (Türkiye), Turkey (Türkiye)
Mersin Üniversitesi Tip Fakültesi Hastanesi- Çiftlikköy Yerleşkesi- Hematoloji
MersinTurkey (Türkiye), Turkey (Türkiye)
VM Medical Park Mersin Hastanesi- Kardiyoloji
MersinTurkey (Türkiye), Turkey (Türkiye)
VM Medical Park Mersin Hastanesi- Hematoloji
MersinTurkey (Türkiye), Turkey (Türkiye)
CHU Saint-Pierre - UMC Sint-Pieter
BruxellesBelgium, Belgium
CHU - UVC Brugmann
BruxellesBelgium, Belgium
HUB - Hôpital Erasme
BruxellesBelgium, Belgium
CHU Saint-Pierre - UMC Sint-Pieter
BrusselsBelgium, Belgium
CHU - UVC Brugmann
BrusselsBelgium, Belgium
HUB - Hôpital Erasme
BrusselsBelgium, Belgium
UZ Leuven - Kindergeneeskunde
LeuvenBelgium, Belgium
Acibadem Adana Hastanesi
AdanaTurkey (Türkiye), Turkey (Türkiye)
Baskent Universitesi Adana
AdanaTurkey (Türkiye), Turkey (Türkiye)
Cukurova University Medical Faculty
AdanaTurkey (Türkiye), Turkey (Türkiye)
Acıbadem Adana Hastanesi-Hematoloji
AdanaTurkey (Türkiye), Turkey (Türkiye)
Başkent Üniversitesi Adana Dr. Turgut Noyan Uygulama ve Araştırma Merkezi
AdanaTurkey (Türkiye), Turkey (Türkiye)
Çukurova Üniversitesi Tıp Fakültesi Balcalı Hastanesi- Hematoloji
AdanaTurkey (Türkiye), Turkey (Türkiye)
Başkent Üniversitesi Adana-Hematoloji
AdanaTurkey (Türkiye), Turkey (Türkiye)
Acibadem Adana Hastanesi
AdanaTurkey, Turkey
Baskent Universitesi Adana
AdanaTurkey, Turkey
Cukurova University Medical Faculty
AdanaTurkey, Turkey
UZ Antwerpen - UZA - Haematology
EdegemBelgium, Belgium
UZ Antwerpen - UZA - Kinderhemato-Oncologie
EdegemBelgium, Belgium
Whittington Hospital
LondonUnited Kingdom, United Kingdom
Guy's Hospital
LondonUnited Kingdom, United Kingdom
Kings College Hospital
LondonUnited Kingdom, United Kingdom
Imperial College London
LondonUnited Kingdom, United Kingdom
King's College Hospital - Paediatric Research
LondonUnited Kingdom, United Kingdom
Kings College Hospital - Haematology
LondonUnited Kingdom, United Kingdom
Guy's Hospital - Haematology
LondonUnited Kingdom, United Kingdom
Hacettepe University Hematology
AnkaraTurkey, Turkey
Hacettepe University Hematology
AnkaraTurkey (Türkiye), Turkey (Türkiye)
Hacettepe Üniversitesi Hastanesi- Hematoloji
AnkaraTurkey (Türkiye), Turkey (Türkiye)
Erasmus MC
RotterdamNetherlands, Netherlands
Addenbrooke's Hospital
CambridgeUnited Kingdom, United Kingdom
Addenbrooke's Hospital - Haemophilia and Thrombophilia
CambridgeUnited Kingdom, United Kingdom
HC da FMUSP Hospital das Clínicas São Paulo
São Paulo, SPBrazil, Brazil
Hospital Samaritano Higienópolis - Instituto de Conhecimento Ensino e Pesquisa (ICEP)
São PauloBrazil, Brazil
HC da FMUSP Hospital das Clínicas São Paulo
São Paulo, São PauloBrazil, Brazil
Haga Ziekenhuis
Den HaagNetherlands, Netherlands
Haga Ziekenhuis
The HagueNetherlands, Netherlands
HagaZiekenhuis
The HagueNetherlands, Netherlands
Fundação Hemocentro de Ribeirão Preto
Ribeirão Preto, SãoBrazil, Brazil
Hemocentro UNICAMP
Distrito De Barão Geraldo - Campinas, São PauloBrazil, Brazil
UMC Utrecht, Van Creveldkliniek
UtrechtNetherlands, Netherlands
Amsterdam UMC Lokatie VUMC
AmsterdamNetherlands, Netherlands
AmsterdamUMC VUMC - Hematologie
AmsterdamNetherlands, Netherlands
King Faisal Specialist Hospital & Research Centre, Riyadh
RiyadhSaudi Arabia, Saudi Arabia
King Khalid University Hospital
RiyadhSaudi Arabia, Saudi Arabia
King Abdulaziz Hospital-Al Ahsa-National Guard
Al AhsaSaudi Arabia, Saudi Arabia
National Guard Hospital Dammam
DhahranSaudi Arabia, Saudi Arabia
Prince Mohammed bin Fahad Hospital for Blood Disorders
Al QaţīfSaudi Arabia, Saudi Arabia
Sultan Qaboos University Hospital
MuscatOman, Oman
Sultan Qaboos University Hospital
Muscat, Sultanet of Oman/Muscat/Al KhoudOman, Oman
Sociedad de Oncología y Hematología del Cesar SAS (SOHEC)
Valledupar, CesarColombia, Colombia
Sociedad de Oncología y Hematología del Cesar SAS (SOHEC)
Valledupar, Cesar DepartmentColombia, Colombia
Sociedad de Oncología y Hematología del Cesar SAS (SOHEC)
AntioquiaColombia, Colombia
Clinica de la Costa
Barranquilla, AtlánticoColombia, Colombia
Clinica de la Costa
BarranquillaColombia, Colombia
Hospital Pablo Tobon Uribe
Medellin, AntioquiaColombia, Colombia
Hospital Pablo Tobon Uribe
MedellinColombia, Colombia
Nirmal Hospital Pvt. Ltd.
Surat, GujaratIndia, India
Clínica IMAT Oncomedica Auna S.A.S.
MonteriaColombia, Colombia
Clínica IMAT Oncomedica Auna S.A.S.
Montería, Departamento de CórdobaColombia, Colombia
Clínica IMAT Oncomedica Auna S.A.S.
Monteria, CórdobaColombia, Colombia
SSG Hospital, Baroda
Vadodara, GujaratIndia, India
HOCC Haemato Oncology Care Centre
Vadodara, GujaratIndia, India
Centro de investigaciones clínicas, fudación valle del lili
CaliColombia, Colombia
Centro de investigaciones clínicas, fudación valle del lili
Santiago de Cali, Valle del Cauca DepartmentColombia, Colombia
Centro de investigaciones clínicas, fudación valle del lili
Santiago de CaliColombia, Colombia
Centro de investigaciones clínicas, fudación valle del lili
Cali, Valle del Cauca DepartmentColombia, Colombia
Fundacion Valle del Lili
Cali, Valle del Cauca DepartmentColombia, Colombia
Centro de investigaciones clínicas, fudación valle del lili
Cali, Valle Del CaucaColombia, Colombia
Government Medical College, Kozhikode
Kozhikode, KeralaIndia, India
JSS Hospital, Mysore
Mysuru, KarnatakaIndia, India
Zydus Medical College & Hospital
Dohad, GujaratIndia, India
RNT Medical College
Udaipur, RajasthanIndia, India
NIZAM'S Institute of Medical Sciences
Hyderabad, TelanganaIndia, India
Zydus Medical College & Hospital
Dahod, GujaratIndia, India
Arihant Multispeciality Hospital
Nagpur, MaharashtraIndia, India
All India Institute of Medical Sciences_New Dehli
New DelhiIndia, India
Post Graduate Institute of Child Health
Noida, Uttar PradeshIndia, India
Boston Medical Center
Boston, MassachusettsUnited States, United States
Boston Children's Hospital
Boston, MassachusettsUnited States, United States
Memorial Healthcare
Hollywood, FloridaUnited States, United States
Cohen Children's Medical Ctr
Queens, New YorkUnited States, United States
All India Institute of Medical Sciences (AIIMS), Raipur
Raipur, ChhattisgarhIndia, India
NYC Health+Hospitals
Brooklyn, New YorkUnited States, United States
Interfaith Medical Center
Brooklyn, New YorkUnited States, United States
Jacobi Medical Center
Bronx, New YorkUnited States, United States
Montefiore Medical Ctr
Bronx, New YorkUnited States, United States
Jacobi Medical Center
The Bronx, New YorkUnited States, United States
Montefiore Medical Ctr
The Bronx, New YorkUnited States, United States
Newark Beth Israel Medical Center
Newark, New JerseyUnited States, United States
Newark Beth Israel MC
Newark, New JerseyUnited States, United States
Children's Hsptl Of The Kings
Norfolk, VirginiaUnited States, United States
St Christopher Hosp for Child
Philadelphia, PennsylvaniaUnited States, United States
Children's Hosptl Philadelphia
Philadelphia, PennsylvaniaUnited States, United States
Children's Hospital Of Philadelphia_Philadelphia
Philadelphia, PennsylvaniaUnited States, United States
East Carolina Univ-Greenville
Greenville, North CarolinaUnited States, United States
East Carolina University_Greenville_0
Greenville, North CarolinaUnited States, United States
Nemours/AI duPont Hosp-Chld
Wilmington, DelawareUnited States, United States
Virginia Comm Univ Medical Ctr
Richmond, VirginiaUnited States, United States
Childrens National Medical Ctr
Washington, District of ColumbiaUnited States, United States
MedStar Hlth Res Institute
Washington, District of ColumbiaUnited States, United States
Childrens National Medical Ctr
Washington D.C., District of ColumbiaUnited States, United States
MedStar Hlth Res Institute
Washington D.C., District of ColumbiaUnited States, United States
Inova Health System
Fairfax, VirginiaUnited States, United States
CHUM-Hosp de Univ Montreal
Montreal, QuebecCanada, Canada
Montreal Children's Hospital
Montreal, QuebecCanada, Canada
Duke University Medical Center
Durham, North CarolinaUnited States, United States
Duke Comprehen Sickle Cell
Durham, North CarolinaUnited States, United States
Atrium Health-Wake Forest Bapt
Winston-Salem, North CarolinaUnited States, United States
IMS and SUM Hospital
Bhubaneswar, OrissaIndia, India
IMS and SUM Hospital
Bhubaneswar, OdishaIndia, India
Scarborough Health Network Research Institute (SHNRI)
Scarborough Village, OntarioCanada, Canada
University of Toronto
Toronto, OntarioCanada, Canada
Children's Healthcare Atlanta
Atlanta, GeorgiaUnited States, United States
Univ Hosp Cleveland Med Ctr
Cleveland, OhioUnited States, United States
LHSC - Victoria Hospital
London, OntarioCanada, Canada
Ohio State Univ Wexner Med Ctr
Columbus, OhioUnited States, United States
Uni of Alabama at Birmingham
Birmingham, AlabamaUnited States, United States
Univer South Alabama Ped/Onc
Mobile, AlabamaUnited States, United States
Children's Hosp-New Orleans
New Orleans, LouisianaUnited States, United States
Gauhati Medical College and Hospital
Guwahati, AssamIndia, India
Methodist University Hospital
Memphis, TennesseeUnited States, United States
St. Jude Children's Res Hosp
Memphis, TennesseeUnited States, United States
University of Tennessee Health Science Center
Memphis, TennesseeUnited States, United States
Childrens Hospital of Chicago
Chicago, IllinoisUnited States, United States
Univer Of Illinois at Chicago
Chicago, IllinoisUnited States, United States
Washington University-St.Louis
Saint Louis, MissouriUnited States, United States
Washington University-St.Louis
St Louis, MissouriUnited States, United States
Arkansas Children's Hospital
Little Rock, ArkansasUnited States, United States
UT Health University of Texas
Houston, TexasUnited States, United States
University of Minnesota
Minneapolis, MinnesotaUnited States, United States
Univ of OK Health Sciences Ctr
Oklahoma City, OklahomaUnited States, United States
Children's Nebraska
Omaha, NebraskaUnited States, United States
Phoenix Children's Hsptl
Phoenix, ArizonaUnited States, United States
Fiona Stanley Hospital - Haemophilia and Haemostasis Centre
Murdoch, Western AustraliaAustralia, Australia
Fiona Stanley Hospital - Haemophilia and Haemostasis Centre
Murdoch, Western AustraliaAustralia, Australia
Children's Hospital Los Angeles - Endocrinology
Los Angeles, CaliforniaUnited States, United States
UCLA Health
Los Angeles, CaliforniaUnited States, United States
Harbor-UCLA Medical Center
Torrance, CaliforniaUnited States, United States
Foothills Med Ctr-Univ Calgary
Calgary, AlbertaCanada, Canada
Stollery Children's Hospital
Edmonton, AlbertaCanada, Canada
University of Alberta_Edmonton
Edmonton, AlbertaCanada, Canada
Valley Children's Hospital
Madera, CaliforniaUnited States, United States
Stanford University_Palo Alto
Palo Alto, CaliforniaUnited States, United States
Mary Bridge Children's Health
Tacoma, WashingtonUnited States, United States
BC Children's Hospital
Vancouver, British ColumbiaCanada, Canada
St Pauls Hospital
Vancouver, British ColumbiaCanada, Canada
Monash Medical Centre - Haematology Department
Clayton, VictoriaAustralia, Australia
Monash Health
Clayton, VictoriaAustralia, Australia
Royal Prince Alfred Hospital - Department of Haematology
Camperdown, New South WalesAustralia, Australia
Royal Prince Alfred Hospital
Camperdown, New South WalesAustralia, Australia
Prince of Wales Hospital - Department of Haematology
Randwick, New South WalesAustralia, Australia
Prince of Wales Hospital - Department of Haematology
Randwick, New South WalesAustralia, Australia
Prince of Wales Hospital
Randwick, New South WalesAustralia, Australia

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